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Yes, the franchise is still alive -- but you'll want to forget that from years ago. Bethesda used its E3 event to a series reboot, simply called Prey, that shares little (if anything) in common with either the 2006 original or the since-discarded follow-up. Arkane's shooter puts you in the shoes of Morgan Yu, an experimental subject plunked aboard a space station and tracked down by invading aliens. You'll have to use weapons, tools, and "mind-bending abilities" to win. Bethesda is only committing to a 2017 release window, but the new Prey will ship for PC, PS4 and Xbox One.
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